Purine N-Oxides
نویسندگان
چکیده
منابع مشابه
Purine N-oxides. XVI. Oncogenic derivatives of xanthine and guanine.
The oxidation of guanine to an N-oxide and its hydrolysis to a xanthine N-oxide are rejorted. The s.c. administration of the xanthine N-oxide to rats for 6 months resulted in development of a variety of tumors. There were 1 liposarcoma, 3 fibrosarcomas, 1 nmmmary adenocarcinoma, 3 fibrohlastic tumors, 2 rhabdomyosarcomas, and 1 epideiinoid carcinoma at the site of injection and elsewhere in 11 ...
متن کاملMutagenicity of derivatives of the oncogenic purine N-oxides.
Acetoxy esters of purine W-oxides inactivate and induce mutations in Bacillus jwà ̈n/Ã1-transforming DNA. The es ters were the chemical models available for the sulfate es ters believed to be formed in vivo. When metabolic suscep tibilities were taken into consideration, there is a reasonable correlation between the mutagenicity of various acetoxy es ters and the oncogenicity of the parent W-oxi...
متن کاملAlkaloid N-oxides of Amaryllidaceae
Ungiminorine N-oxide was isolated from Puncrutium maritimum, and homolycorine N-oxide and O-methyl lycorenine N-oxide from Lapiedra martinezii. These compounds represent the first examples of naturally occurring Noxides from the Amaryllidaceae.
متن کاملREACTIVITY OF N-SUBSTITUTED p-BENZO AND p-NAPHTHOQUINONEIMINE N-OXIDES TOWARD DIPOLAROPHILES
The dipolar cycloaddition reactivity of N-(1-naphthy1)-1,4- benzoquinoneimine N-oxide and N-phenyl-1,4- naphthoquinoneimine Noxide are investigated, The latter gives the expected adducts with common dipolarophiles such as acrylonitryle, methyl methacrylate, dimethylacetylene dicarboxylate and N-phenylmaleimide. The reactivity of the former nitrone is found to be minimal. It undergoes, how...
متن کاملRegioselective bromination of fused heterocyclic N-oxides.
A mild method for the regioselective C2-bromination of fused azine N-oxides is presented, employing tosic anhydride as the activator and tetra-n-butylammonium bromide as the nucleophilic bromide source. The C2-brominated compounds are produced in moderate to excellent yields and with excellent regioselectivity in most cases. The potential extension of this method to other halogens, effecting C2...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1969
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)78249-0